Lymphadenopathy in toxoplasmosis.

The clinical signs of congenital toxoplasmosis are now well known, but those of post-natally acquired infections have received less attention. Sabin (1941) recorded two cases which presented as meningoencephalitis, and Pinkerton and Henderson (1941) described two cases which resembled typhus. In 1951 Siim reported seven cases which had generalized lymph node enlargement not unlike glandular fever. Since then many other cases of lymphadenopathy have been described (see Siim, 1956). The latter type of illness appears to be much commoner than the others described. In most cases there have been abnormal cells of the lymphocyte-monocyte series in the peripheral blood and in none of them has the Paul-Bunnell test been positive. In only a few cases have lymph nodes been submitted to histological examination, and the purpose of this report is to describe a case in which the histological appearance resembled that described by Robb-Smith (1947) as lympho-histiocytic medullary reticulosis.